Drug expiration dating calculations

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The calculator has been field tested by veterinary technicians within the University of California, San Francisco (UCSF) Laboratory Animal Resource Center on a range of mouse cases.

The Challenges of Compounding Commercially produced preparations of drugs in concentrations ideal for mice are not readily available.

Desired Dose (mg/kg)  Animal Weight (kg)/Drug Stock Concentration (mg/m L)= Stock Administration Volume (m L) Once the volume of stock agent has been calculated, this volume is then combined with an appropriate volume of dilutant to yield the final volume.

An acceptable volume for the final injection amount should take into consideration the size of the animal to ensure complete absorption of the agent without causing discomfort or pain.

Since recommended drug dosages in mice may change as more research becomes available, users are always encouraged to consult the current literature or their animal care department for drug dose recommendations.

The calculator file is divided between two sheets: “Calculator” serves as the user interface, requiring inputs and displaying instructions on how to prepare drugs; and “Formulary” includes the raw data such as stock concentrations and other internal metrics.

Post-dilution, the working concentration of this solution is calculated using the formula shown below.An inappropriate dilution or a miscalculated dose can result in excessive anesthesia or death of the animal.To simplify and streamline the process of mouse drug dilution and calculation, we have created an electronic dosage calculator in Microsoft Excel for administering injectable anesthetics and analgesics to mice.Figure 1: Screenshots of the Mouse Dosage Calculator that depict each of the six required steps.Steps 1-4 (ad) solicit input from the user on their preferred dosing parameters.

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